Dose adjustment of irinotecan based on UGT1A1 polymorphisms in patients with colorectal cancer

PURPOSE: Irinotecan is effective for metastatic colorectal cancer (mCRC). SN-38 is an active metabolite of irinotecan, which is formed by carboxylesterase and inactivated by UDP-glucuronyltransferase (UGT) 1A1. The UGT enzyme activity is reduced in patients with homozygous mutation in UGT1A1 genes (...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Chemother Pharmacol
Main Authors: Fujii, Hironori, Yamada, Yunami, Watanabe, Daichi, Matsuhashi, Nobuhisa, Takahashi, Takao, Yoshida, Kazuhiro, Suzuki, Akio
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2018
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373181/
https://ncbi.nlm.nih.gov/pubmed/30377777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-018-3711-8
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