Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas chang...

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Bibliographische Detailangaben
Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Austin, Philip J., Tsitsiou, Eleni, Boardman, Charlotte, Jones, Simon W., Lindsay, Mark A., Adcock, Ian M., Chung, Kian Fan, Perry, Mark M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2017
Schlagworte:
Asthma and Lower Airway Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338875/
https://ncbi.nlm.nih.gov/pubmed/27484035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.06.014
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