Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas chang...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Austin, Philip J., Tsitsiou, Eleni, Boardman, Charlotte, Jones, Simon W., Lindsay, Mark A., Adcock, Ian M., Chung, Kian Fan, Perry, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2017
Assuntos:
Asthma and Lower Airway Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338875/
https://ncbi.nlm.nih.gov/pubmed/27484035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.06.014
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