Transcriptional profiling identifies the long noncoding RNA plasmacytoma variant translocation (PVT1) as a novel regulator of the asthmatic phenotype in human airway smooth muscle

BACKGROUND: The mechanism underlying nonsevere and severe asthma remains unclear, although it is commonly associated with increased airway smooth muscle (ASM) mass. Long noncoding RNAs (lncRNAs) are known to be important in regulating healthy primary airway smooth muscle cells (ASMCs), whereas chang...

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Vydáno v:J Allergy Clin Immunol
Hlavní autoři: Austin, Philip J., Tsitsiou, Eleni, Boardman, Charlotte, Jones, Simon W., Lindsay, Mark A., Adcock, Ian M., Chung, Kian Fan, Perry, Mark M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mosby 2017
Témata:
Asthma and Lower Airway Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338875/
https://ncbi.nlm.nih.gov/pubmed/27484035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.06.014
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