Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

IL-1 family member interleukin 37 (IL-37) has broad antiinflammatory properties and functions as a natural suppressor of innate inflammation. In this study, we demonstrate that treatment with recombinant human IL-37 reverses the decrease in exercise performance observed during systemic inflammation....

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Cavalli, Giulio, Justice, Jamie N., Boyle, Kristen E., D’Alessandro, Angelo, Eisenmesser, Elan Z., Herrera, Jonathan J., Hansen, Kirk C., Nemkov, Travis, Stienstra, Rinke, Garlanda, Cecilia, Mantovani, Alberto, Seals, Douglas R., Dagna, Lorenzo, Joosten, Leo A. B., Ballak, Dov B., Dinarello, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338542/
https://ncbi.nlm.nih.gov/pubmed/28193888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619011114
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