Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

IL-1 family member interleukin 37 (IL-37) has broad antiinflammatory properties and functions as a natural suppressor of innate inflammation. In this study, we demonstrate that treatment with recombinant human IL-37 reverses the decrease in exercise performance observed during systemic inflammation....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cavalli, Giulio, Justice, Jamie N., Boyle, Kristen E., D’Alessandro, Angelo, Eisenmesser, Elan Z., Herrera, Jonathan J., Hansen, Kirk C., Nemkov, Travis, Stienstra, Rinke, Garlanda, Cecilia, Mantovani, Alberto, Seals, Douglas R., Dagna, Lorenzo, Joosten, Leo A. B., Ballak, Dov B., Dinarello, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338542/
https://ncbi.nlm.nih.gov/pubmed/28193888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619011114
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