Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation

Objectives. The IL-1 family member IL-37 was recently characterized as a fundamental inhibitor of innate inflammation. We investigated the effects of recombinant IL-37 in joint inflammation and joint pathology in a mouse model of arthritis. In addition, we explored the potential for therapeutic use...

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Veröffentlicht in:Rheumatology (Oxford)
Hauptverfasser: Cavalli, Giulio, Koenders, Marije, Kalabokis, Vassili, Kim, Jihye, Tan, Aik Choon, Garlanda, Cecilia, Mantovani, Alberto, Dagna, Lorenzo, Joosten, Leo A. B., Dinarello, Charles A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Basic and Translational Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144668/
https://ncbi.nlm.nih.gov/pubmed/27567100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kew325
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