TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity

TGF-β is an anti-inflammatory cytokine whose signaling is negatively controlled by Smad7. Previously, we established a role for Smad7 in the generation of autoreactive T cells; however, the function of Smad7 in dendritic cells (DCs) remains elusive. Here, we demonstrate that DC-specific Smad7 defici...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lukas, Dominika, Yogev, Nir, Kel, Junda M., Regen, Tommy, Mufazalov, Ilgiz A., Tang, Yilang, Wanke, Florian, Reizis, Boris, Müller, Werner, Kurschus, Florian C., Prinz, Marco, Kleiter, Ingo, Clausen, Björn E., Waisman, Ari
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338403/
https://ncbi.nlm.nih.gov/pubmed/28167776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615065114
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