Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brain barrier (BBB) endothelial cells (ECs), astrocytes...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Hauptmann, Judith, Johann, Lisa, Marini, Federico, Kitic, Maja, Colombo, Elisa, Mufazalov, Ilgiz A., Krueger, Martin, Karram, Khalad, Moos, Sonja, Wanke, Florian, Kurschus, Florian C., Klein, Matthias, Cardoso, Silvia, Strauß, Judith, Bolisetty, Subhashini, Lühder, Fred, Schwaninger, Markus, Binder, Harald, Bechman, Ingo, Bopp, Tobias, Agarwal, Anupam, Soares, Miguel P., Regen, Tommy, Waisman, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498485/
https://ncbi.nlm.nih.gov/pubmed/32651669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02187-x
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