Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brain barrier (BBB) endothelial cells (ECs), astrocytes...

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Pubblicato in:Acta Neuropathol
Autori principali: Hauptmann, Judith, Johann, Lisa, Marini, Federico, Kitic, Maja, Colombo, Elisa, Mufazalov, Ilgiz A., Krueger, Martin, Karram, Khalad, Moos, Sonja, Wanke, Florian, Kurschus, Florian C., Klein, Matthias, Cardoso, Silvia, Strauß, Judith, Bolisetty, Subhashini, Lühder, Fred, Schwaninger, Markus, Binder, Harald, Bechman, Ingo, Bopp, Tobias, Agarwal, Anupam, Soares, Miguel P., Regen, Tommy, Waisman, Ari
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2020
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498485/
https://ncbi.nlm.nih.gov/pubmed/32651669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02187-x
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