Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier

The proinflammatory cytokine interleukin 1 (IL-1) is crucially involved in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Herein, we studied the role of IL-1 signaling in blood–brain barrier (BBB) endothelial cells (ECs), astrocytes...

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Опубликовано в: :Acta Neuropathol
Главные авторы: Hauptmann, Judith, Johann, Lisa, Marini, Federico, Kitic, Maja, Colombo, Elisa, Mufazalov, Ilgiz A., Krueger, Martin, Karram, Khalad, Moos, Sonja, Wanke, Florian, Kurschus, Florian C., Klein, Matthias, Cardoso, Silvia, Strauß, Judith, Bolisetty, Subhashini, Lühder, Fred, Schwaninger, Markus, Binder, Harald, Bechman, Ingo, Bopp, Tobias, Agarwal, Anupam, Soares, Miguel P., Regen, Tommy, Waisman, Ari
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2020
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7498485/
https://ncbi.nlm.nih.gov/pubmed/32651669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-020-02187-x
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