Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant

Stress-response transcription factors such as NFκB turn on hundreds of genes and must have a mechanism for rapid cessation of transcriptional activation. We recently showed that the inhibitor of NFκB signaling, IκBα, dramatically accelerates the dissociation of NFκB from transcription sites, a proce...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dembinski, Holly E., Wismer, Kevin, Vargas, Jesse D., Suryawanshi, Gajendra W., Kern, Nadja, Kroon, Gerard, Dyson, H. Jane, Hoffmann, Alexander, Komives, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338396/
https://ncbi.nlm.nih.gov/pubmed/28167786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610192114
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