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Superagonism at G protein‐coupled receptors and beyond

Ligands targeting GPCRs can be categorized according to their intrinsic efficacy to trigger a specific, receptor‐mediated response. A ligand endowed with the same level of efficacy as the endogenous agonist can be classified as a full agonist, whereas a compound that displays greater efficacy, that...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Schrage, R, De Min, A, Hochheiser, K, Kostenis, E, Mohr, K
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338155/
https://ncbi.nlm.nih.gov/pubmed/26276510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13278
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