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Compromising KCC2 transporter activity enhances the development of continuous seizure activity

Impaired neuronal inhibition has long been associated with the increased probability of seizure occurrence and heightened seizure severity. Fast synaptic inhibition in the brain is primarily mediated by the type A γ-aminobutyric acid receptors (GABA(A)Rs), ligand-gated ion channels that can mediate...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuropharmacology
Prif Awduron: Kelley, Matthew R., Deeb, Tarek Z., Brandon, Nicholas J., Dunlop, John, Davies, Paul A., Moss, Stephen J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5337122/
https://ncbi.nlm.nih.gov/pubmed/27108931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.04.029
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