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Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities

Alkylation chemotherapy is one of the most widely used systemic therapies for cancer. While somewhat effective, clinical responses and toxicities of these agents are highly variable. A major contributing factor for this variability is the numerous distinct lesions that are created upon alkylation da...

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Detalhes bibliográficos
Publicado no:Trends Biochem Sci
Main Authors: Soll, Jennifer M., Sobol, Robert W., Mosammaparast, Nima
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336464/
https://ncbi.nlm.nih.gov/pubmed/27816326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2016.10.001
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