Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of T(H)1 and T(H)17 cytokines in protection and pathology

Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4(+) T(H)1 and cytotoxic...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Negl Trop Dis
Main Authors: Moderzynski, Kristin, Heine, Liza, Rauch, Jessica, Papp, Stefanie, Kuehl, Svenja, Richardt, Ulricke, Fleischer, Bernhard, Osterloh, Anke
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336310/
https://ncbi.nlm.nih.gov/pubmed/28222146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005404
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items