Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of T(H)1 and T(H)17 cytokines in protection and pathology

Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4(+) T(H)1 and cytotoxic...

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Detaylı Bibliyografya
Yayımlandı:PLoS Negl Trop Dis
Asıl Yazarlar: Moderzynski, Kristin, Heine, Liza, Rauch, Jessica, Papp, Stefanie, Kuehl, Svenja, Richardt, Ulricke, Fleischer, Bernhard, Osterloh, Anke
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336310/
https://ncbi.nlm.nih.gov/pubmed/28222146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005404
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