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Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of T(H)1 and T(H)17 cytokines in protection and pathology
Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4(+) T(H)1 and cytotoxic...
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| Izdano u: | PLoS Negl Trop Dis |
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| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5336310/ https://ncbi.nlm.nih.gov/pubmed/28222146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005404 |
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