Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells

Rickettsia (R.) typhi is the causative agent of endemic typhus, an emerging febrile disease that is associated with complications such as pneumonia, encephalitis and liver dysfunction. To elucidate how innate immune mechanisms contribute to defense and pathology we here analyzed R. typhi infection o...

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Bibliographic Details
Published in:PLoS Negl Trop Dis
Main Authors: Papp, Stefanie, Moderzynski, Kristin, Rauch, Jessica, Heine, Liza, Kuehl, Svenja, Richardt, Ulricke, Mueller, Heidelinde, Fleischer, Bernhard, Osterloh, Anke
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993389/
https://ncbi.nlm.nih.gov/pubmed/27548618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004935
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