Liver Necrosis and Lethal Systemic Inflammation in a Murine Model of Rickettsia typhi Infection: Role of Neutrophils, Macrophages and NK Cells

Rickettsia (R.) typhi is the causative agent of endemic typhus, an emerging febrile disease that is associated with complications such as pneumonia, encephalitis and liver dysfunction. To elucidate how innate immune mechanisms contribute to defense and pathology we here analyzed R. typhi infection o...

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Bibliografiske detaljer
Udgivet i:PLoS Negl Trop Dis
Main Authors: Papp, Stefanie, Moderzynski, Kristin, Rauch, Jessica, Heine, Liza, Kuehl, Svenja, Richardt, Ulricke, Mueller, Heidelinde, Fleischer, Bernhard, Osterloh, Anke
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993389/
https://ncbi.nlm.nih.gov/pubmed/27548618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004935
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