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The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon

The ubiquitin ligase Nedd4-like (Nedd4L, or Nedd4-2) binds to and regulates stability of the epithelial Na(+) channel (ENaC) in salt-absorbing epithelia in the kidney, lung, and other tissues. Its role in the distal colon, which also absorbs salt and fluid and expresses ENaC, is unknown. Using a con...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Jiang, Chong, Kawabe, Hiroshi, Rotin, Daniela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336150/
https://ncbi.nlm.nih.gov/pubmed/28087701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770065
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