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A Role for the Ubiquitin Ligase Nedd4 in Membrane Sorting of LAPTM4 Proteins

BACKGROUND: The Lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b, with the latter previously shown to be overexpressed in numerous cancers. While we had demonstrated earlier the requirement of the E3 ubiquitin ligase Nedd4 for LAPTM5...

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Autores principales: Milkereit, Ruth, Rotin, Daniela
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214061/
https://ncbi.nlm.nih.gov/pubmed/22096579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027478
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