Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated with autophagy dysregulation, and drugs modulating autophagy have been successful in several animal models. Microglial cell...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Bussi, Claudio, Ramos, Javier Maria Peralta, Arroyo, Daniela S., Gaviglio, Emilia A., Gallea, Jose Ignacio, Wang, Ji Ming, Celej, Maria Soledad, Iribarren, Pablo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335665/
https://ncbi.nlm.nih.gov/pubmed/28256519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43153
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