Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

Autophagy is a fundamental cellular homeostatic mechanism, whereby cells autodigest parts of their cytoplasm for removal or turnover. Neurodegenerative disorders are associated with autophagy dysregulation, and drugs modulating autophagy have been successful in several animal models. Microglial cell...

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Published in:Sci Rep
Main Authors: Bussi, Claudio, Ramos, Javier Maria Peralta, Arroyo, Daniela S., Gaviglio, Emilia A., Gallea, Jose Ignacio, Wang, Ji Ming, Celej, Maria Soledad, Iribarren, Pablo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5335665/
https://ncbi.nlm.nih.gov/pubmed/28256519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43153
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