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Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation
Histone H3 lysine 36 methylation (H3K36me) is critical for epigenetic regulation and mutations at or near H3K36 are associated with distinct types of cancers. H3K36M dominantly inhibits H3K36me on wild-type histones, whereas H3G34R/V selectively affects H3K36me on the same histone tail. Here we repo...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5335568/ https://ncbi.nlm.nih.gov/pubmed/28256625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43906 |
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