A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial. Here we show that in fission yeast, introduc...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Shan, Chun-Min, Wang, Jiyong, Xu, Ke, Chen, Huijie, Yue, Jia-Xing, Andrews, Stuart, Moresco, James J, Yates, John R, Nagy, Peter L, Tong, Liang, Jia, Songtao
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030085/
https://ncbi.nlm.nih.gov/pubmed/27648579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17903
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