Nuclear RanGAP Is Required for the Heterochromatin Assembly and Is Reciprocally Regulated by Histone H3 and Clr4 Histone Methyltransferase in Schizosaccharomyces pombe

Although the Ran GTPase-activating protein RanGAP mainly functions in the cytoplasm, several lines of evidence indicate a nuclear function of RanGAP. We found that Schizosaccharomyces pombe RanGAP, SpRna1, bound the core of histone H3 (H3) and enhanced Clr4-mediated H3-lysine 9 (K9) methylation. Thi...

Full description

Saved in:
Bibliographic Details
Main Authors: Nishijima, Hitoshi, Nakayama, Jun-ichi, Yoshioka, Tomoko, Kusano, Ayumi, Nishitani, Hideo, Shibahara, Kei-ichi, Nishimoto, Takeharu
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2006
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474784/
https://ncbi.nlm.nih.gov/pubmed/16540522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-09-0893
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items