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Nuclear RanGAP Is Required for the Heterochromatin Assembly and Is Reciprocally Regulated by Histone H3 and Clr4 Histone Methyltransferase in Schizosaccharomyces pombe

Although the Ran GTPase-activating protein RanGAP mainly functions in the cytoplasm, several lines of evidence indicate a nuclear function of RanGAP. We found that Schizosaccharomyces pombe RanGAP, SpRna1, bound the core of histone H3 (H3) and enhanced Clr4-mediated H3-lysine 9 (K9) methylation. Thi...

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Detalhes bibliográficos
Main Authors: Nishijima, Hitoshi, Nakayama, Jun-ichi, Yoshioka, Tomoko, Kusano, Ayumi, Nishitani, Hideo, Shibahara, Kei-ichi, Nishimoto, Takeharu
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474784/
https://ncbi.nlm.nih.gov/pubmed/16540522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-09-0893
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