Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response

The unfolded protein response (UPR) is a conserved signalling pathway activated on the accumulation of unfolded proteins within the endoplasmic reticulum (ER), termed ER stress. Upon ER stress, HAC1/XBP1 undergoes exon/intron-specific excision by inositol requiring enzyme 1 (IRE1) to remove an intro...

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Bibliographic Details
Published in:Biosci Rep
Main Authors: Poothong, Juthakorn, Tirasophon, Witoon, Kaufman, Randal J.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5333776/
https://ncbi.nlm.nih.gov/pubmed/28093457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20160574
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