The LINK-A lncRNA interacts with PI(3,4,5)P(3) to hyperactivate AKT and confer resistance to AKT inhibitors

Phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) mediates signaling pathways as a second messenger in response to extracellular signals. Although primordial functions of phospholipids and RNAs have been hypothesized in the “RNA world”, physiological RNA-phospholipid interactions and their involveme...

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Gepubliceerd in:Nat Cell Biol
Hoofdauteurs: Lin, Aifu, Hu, Qingsong, Li, Chunlai, Xing, Zhen, Ma, Guolin, Wang, Cheng, Li, Jun, Ye, Yin, Yao, Jun, Liang, Ke, Wang, Shouyu, Park, Peter K., Marks, Jeffrey R., Zhou, Yan, Zhou, Jianwei, Hung, Mien-Chie, Liang, Han, Hu, Zhibin, Shen, Hongbing, Hawke, David H., Han, Leng, Zhou, Yubin, Lin, Chunru, Yang, Liuqing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332298/
https://ncbi.nlm.nih.gov/pubmed/28218907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3473
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