A ROR1-HER3-LncRNA signaling axis modulates the Hippo-YAP pathway to regulate bone metastasis

Bone metastases remain as a serious health concern because of limited therapeutic options. Here, we report that crosstalk between ROR1-HER3 and the Hippo-YAP pathway promotes breast cancer bone metastasis in a long noncoding RNA-dependent fashion. Mechanistically, the orphan receptor tyrosine kinase...

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Udgivet i:Nat Cell Biol
Main Authors: Li, Chunlai, Wang, Shouyu, Xing, Zhen, Lin, Aifu, Liang, Ke, Song, Jian, Hu, Qingsong, Yao, Jun, Chen, Zhongyuan, Park, Peter K., Hawke, David H., Zhou, Jianwei, Zhou, Yan, Zhang, Shuxing, Liang, Han, Hung, Mien-Chie, Gallick, Gary E., Han, Leng, Lin, Chunru, Yang, Liuqing
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336186/
https://ncbi.nlm.nih.gov/pubmed/28114269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3464
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