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The LINK-A lncRNA interacts with PI(3,4,5)P(3) to hyperactivate AKT and confer resistance to AKT inhibitors
Phosphatidylinositol-3,4,5-trisphosphate (PIP(3)) mediates signaling pathways as a second messenger in response to extracellular signals. Although primordial functions of phospholipids and RNAs have been hypothesized in the “RNA world”, physiological RNA-phospholipid interactions and their involveme...
שמור ב:
| הוצא לאור ב: | Nat Cell Biol |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5332298/ https://ncbi.nlm.nih.gov/pubmed/28218907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3473 |
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