Stabilization of HIF-1α and HIF-2α, up-regulation of MYCC and accumulation of stabilized p53 constitute hallmarks of CNS-PNET animal model

Recently, we described a new animal model of CNS primitive neuroectodermal tumors (CNS-PNET), which was generated by orthotopic transplantation of human Radial Glial (RG) cells into NOD-SCID mice’s brain sub-ventricular zone. In the current study we conducted comprehensive RNA-Seq analyses to gain i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Malchenko, Sergey, Sredni, Simone Treiger, Bi, Yingtao, Margaryan, Naira V., Boyineni, Jerusha, Mohanam, Indra, Tomita, Tadanori, Davuluri, Ramana V., Soares, Marcelo B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5332108/
https://ncbi.nlm.nih.gov/pubmed/28249000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173106
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