Regulation of HIF-1α Stability through S-nitrosylation

Hypoxia inducible factor 1 (HIF-1) is a master transcriptional factor. Under normal oxygen tension, HIF-1 activity is usually suppressed due to the rapid, oxygen-dependent degradation of one of its two subunits, HIF-1α. Here we report that normoxic HIF-1 activity can be up-regulated through NO-media...

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Autori principali: Li, Fang, Sonveaux, Pierre, Rabbani, Zahid N., Liu, Shanling, Yan, Bin, Huang, Qian, Vujaskovic, Zeljko, Dewhirst, Mark W., Li, Chuan-Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905600/
https://ncbi.nlm.nih.gov/pubmed/17434127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.02.024
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