Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2

The stringent expression of the hypoxia inducible factor-1α (HIF-1α) is critical to a variety of pathophysiological conditions. We reveal that, in normoxia, enzymatic action of cystathionine β-synthase (CBS) produces H(2)S, which persulfidates prolyl hydroxylase 2 (PHD2) at residues Cys(21) and Cys(...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Dey, Anindya, Prabhudesai, Shubhangi, Zhang, Yushan, Rao, Geeta, Thirugnanam, Karthikeyan, Hossen, Md. Nazir, Dwivedi, Shailendra Kumar Dhar, Ramchandran, Ramani, Mukherjee, Priyabrata, Bhattacharya, Resham
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458453/
https://ncbi.nlm.nih.gov/pubmed/32937467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8534
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