Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

DNA interstrand cross-links (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. We devised a t...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Räschle, Markus, Smeenk, Godelieve, Hansen, Rebecca K., Temu, Tikira, Oka, Yasuyoshi, Hein, Marco Y., Nagaraj, Nagarjuna, Long, David T., Walter, Johannes C., Hofmann, Kay, Storchova, Zuzana, Cox, Jürgen, Bekker-Jensen, Simon, Mailand, Niels, Mann, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331883/
https://ncbi.nlm.nih.gov/pubmed/25931565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1253671
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