T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone

Functional analysis of T-cell responses in HIV-infected individuals has indicated that virus-specific CD8(+) T cells with superior antiviral efficacy are well represented in HIV-1 controllers but are rare or absent in HIV-1 progressors. To define the role of individual T-cell receptor (TCR) clonotyp...

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Udgivet i:J Virol
Main Authors: Flerin, Nina C., Chen, Huabiao, Glover, Tynisha D., Lamothe, Pedro A., Zheng, Jian Hua, Fang, Justin W., Ndhlovu, Zaza M., Newell, Evan W., Davis, Mark M., Walker, Bruce D., Goldstein, Harris
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Cellular Response to Infection
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331796/
https://ncbi.nlm.nih.gov/pubmed/28077649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02412-16
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