The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function

Immune control of viral infections is modulated by diverse T cell receptor (TCR) clonotypes engaging peptide-MHC class I complexes on infected cells, but the relationship between TCR structure and antiviral function is unclear. Here we apply in silico molecular modeling with in vivo mutagenesis stud...

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Detalhes bibliográficos
Main Authors: Xia, Zhen, Chen, Huabiao, Kang, Seung-gu, Huynh, Tien, Fang, Justin W., Lamothe, Pedro A., Walker, Bruce D., Zhou, Ruhong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3923210/
https://ncbi.nlm.nih.gov/pubmed/24522437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04087
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