Vitamin D Receptor Deficit Induces Activation of Renin Angiotensin System Via SIRT1 Modulation in Podocytes

Vitamin D receptor (VDR) deficient status has been shown to be associated with the activation of renin angiotensin system (RAS). We hypothesized that lack of VDR would enhance p53 expression in podocytes through down regulation of SIRT1; the former would enhance the transcription of angiotensinogen...

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Pubblicato in:Exp Mol Pathol
Autori principali: Chandel, Nirupama, Ayosolla, Kamesh, Wen, Hongxiu, Lan, Xiqian, Haque, Shabirul, Saleem, Moin A., Malhotra, Ashwani, Singhal, Pravin C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331620/
https://ncbi.nlm.nih.gov/pubmed/28069388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2017.01.001
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