Combined Ligand/Structure-Based Virtual Screening and Molecular Dynamics Simulations of Steroidal Androgen Receptor Antagonists

The antiandrogens, such as bicalutamide, targeting the androgen receptor (AR), are the main endocrine therapies for prostate cancer (PCa). But as drug resistance to antiandrogens emerges in advanced PCa, there presents a high medical need for exploitation of novel AR antagonists. In this work, the r...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Wang, Yuwei, Han, Rui, Zhang, Huimin, Liu, Hongli, Li, Jiazhong, Liu, Huanxiang, Gramatica, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331419/
https://ncbi.nlm.nih.gov/pubmed/28293633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/3572394
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