Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56

Protein phosphatase 2A (PP2A) is a critical human tumor suppressor. Cancerous inhibitor of PP2A (CIP2A) supports the activity of several critical cancer drivers (Akt, MYC, E2F1) and promotes malignancy in most cancer types via PP2A inhibition. However, the 3D structure of CIP2A has not been solved,...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Wang, Jiao, Okkeri, Juha, Pavic, Karolina, Wang, Zhizhi, Kauko, Otto, Halonen, Tuuli, Sarek, Grzegorz, Ojala, Päivi M, Rao, Zihe, Xu, Wenqing, Westermarck, Jukka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331240/
https://ncbi.nlm.nih.gov/pubmed/28174209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201642788
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