Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions

In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in‐depth characterization. Using a pipeline designed to suppress stroma‐derived signal, we find...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Picco, Gabriele, Petti, Consalvo, Centonze, Alessia, Torchiaro, Erica, Crisafulli, Giovanni, Novara, Luca, Acquaviva, Andrea, Bardelli, Alberto, Medico, Enzo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5331210/
https://ncbi.nlm.nih.gov/pubmed/28100566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201606773
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