Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infreque...

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發表在:J Clin Invest
Main Authors: Kent, Lindsey N., Bae, Sooin, Tsai, Shih-Yin, Tang, Xing, Srivastava, Arunima, Koivisto, Christopher, Martin, Chelsea K., Ridolfi, Elisa, Miller, Grace C., Zorko, Sarah M., Plevris, Emilia, Hadjiyannis, Yannis, Perez, Miguel, Nolan, Eric, Kladney, Raleigh, Westendorp, Bart, de Bruin, Alain, Fernandez, Soledad, Rosol, Thomas J., Pohar, Kamal S., Pipas, James M., Leone, Gustavo
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330731/
https://ncbi.nlm.nih.gov/pubmed/28134624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87583
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