Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma

Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infreque...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Kent, Lindsey N., Bae, Sooin, Tsai, Shih-Yin, Tang, Xing, Srivastava, Arunima, Koivisto, Christopher, Martin, Chelsea K., Ridolfi, Elisa, Miller, Grace C., Zorko, Sarah M., Plevris, Emilia, Hadjiyannis, Yannis, Perez, Miguel, Nolan, Eric, Kladney, Raleigh, Westendorp, Bart, de Bruin, Alain, Fernandez, Soledad, Rosol, Thomas J., Pohar, Kamal S., Pipas, James M., Leone, Gustavo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330731/
https://ncbi.nlm.nih.gov/pubmed/28134624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87583
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