SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis

Polymorphisms in the PTPN11 gene encoding for the tyrosine phosphatase SHP‐2 were described in patients with ulcerative colitis. We have recently demonstrated that mice with an intestinal epithelial cell‐specific deletion of SHP‐2 (SHP‐2(IEC‐KO)) develop severe colitis 1 month after birth. However,...

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Publicado en:J Cell Physiol
Main Authors: Coulombe, Geneviève, Langlois, Ariane, De Palma, Giada, Langlois, Marie‐Josée, McCarville, Justin L., Gagné‐Sanfaçon, Jessica, Perreault, Nathalie, Feng, Gen‐Sheng, Bercik, Premysl, Boudreau, François, Verdu, Elena F., Rivard, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Original Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330278/
https://ncbi.nlm.nih.gov/pubmed/27100271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25407
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