SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis

Polymorphisms in the PTPN11 gene encoding for the tyrosine phosphatase SHP‐2 were described in patients with ulcerative colitis. We have recently demonstrated that mice with an intestinal epithelial cell‐specific deletion of SHP‐2 (SHP‐2(IEC‐KO)) develop severe colitis 1 month after birth. However,...

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Vydáno v:J Cell Physiol
Hlavní autoři: Coulombe, Geneviève, Langlois, Ariane, De Palma, Giada, Langlois, Marie‐Josée, McCarville, Justin L., Gagné‐Sanfaçon, Jessica, Perreault, Nathalie, Feng, Gen‐Sheng, Bercik, Premysl, Boudreau, François, Verdu, Elena F., Rivard, Nathalie
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Original Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5330278/
https://ncbi.nlm.nih.gov/pubmed/27100271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25407
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