SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development

A major risk factor of developing colorectal cancer (CRC) is the presence of chronic inflammation in the colon. In order to understand how inflammation contributes to CRC development, the present study focused on SHP-2, a tyrosine phosphatase encoded by PTPN11 gene in which polymorphisms have been s...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Gagné-Sansfaçon, Jessica, Coulombe, Geneviève, Langlois, Marie-Josée, Langlois, Ariane, Paquet, Marilene, Carrier, Julie, Feng, Gen-Sheng, Qu, Cheng-Kui, Rivard, Nathalie
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323184/
https://ncbi.nlm.nih.gov/pubmed/27582544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11601
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