Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

Polymorphisms of PTPN11 encoding SHP-2 are biomarkers for ulcerative colitis (UC) susceptibility. However, their functional relevance is unknown. We thus investigated the role of epithelial SHP-2 in the control of intestinal homeostasis. Mice with an intestinal epithelial cell-specific SHP-2 deletio...

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Hauptverfasser: Coulombe, Geneviève, Leblanc, Caroline, Cagnol, Sébastien, Maloum, Faiza, Lemieux, Étienne, Perreault, Nathalie, Feng, Gen-Sheng, Boudreau, François, Rivard, Nathalie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648065/
https://ncbi.nlm.nih.gov/pubmed/23530062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00043-13
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