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Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial

Rationale: The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy in treating patients with pulmonary arterial hypertension (PAH) is unknown. Objectives: We aimed to determine the safety and efficacy of anastr...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Kawut, Steven M., Archer-Chicko, Christine L., DeMichele, Angela, Fritz, Jason S., Klinger, James R., Ky, Bonnie, Palevsky, Harold I., Palmisciano, Amy J., Patel, Mamta, Pinder, Diane, Propert, Kathleen J., Smith, K. Akaya, Stanczyk, Frank, Tracy, Russell, Vaidya, Anjali, Whittenhall, Mary E., Ventetuolo, Corey E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328182/
https://ncbi.nlm.nih.gov/pubmed/27602993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201605-1024OC
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