Anastrozole in Pulmonary Arterial Hypertension. A Randomized, Double-Blind, Placebo-controlled Trial

Rationale: The aromatase inhibitor anastrozole blocks the conversion of androgens to estrogen and blunts pulmonary hypertension in animals, but its efficacy in treating patients with pulmonary arterial hypertension (PAH) is unknown. Objectives: We aimed to determine the safety and efficacy of anastr...

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Опубликовано в: :Am J Respir Crit Care Med
Главные авторы: Kawut, Steven M., Archer-Chicko, Christine L., DeMichele, Angela, Fritz, Jason S., Klinger, James R., Ky, Bonnie, Palevsky, Harold I., Palmisciano, Amy J., Patel, Mamta, Pinder, Diane, Propert, Kathleen J., Smith, K. Akaya, Stanczyk, Frank, Tracy, Russell, Vaidya, Anjali, Whittenhall, Mary E., Ventetuolo, Corey E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Thoracic Society 2017
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328182/
https://ncbi.nlm.nih.gov/pubmed/27602993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201605-1024OC
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