Phagolysosome Acidification is Required for Silica and Engineered Nanoparticle-induced Lysosome Membrane Permeabilization and Resultant NLRP3 Inflammasome Activity

NLRP3 inflammasome activation occurs in response to hazardous particle exposures and is critical for the development of particle-induced lung disease. Mechanisms of Lysosome Membrane Permeabilization (LMP), a central pathway for activation of the NLRP3 inflammasome by inhaled particles, are not full...

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發表在:Toxicol Appl Pharmacol
Main Authors: Jessop, Forrest, Hamilton, Raymond F., Rhoderick, Joseph F., Fletcher, Paige, Holian, Andrij
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5326503/
https://ncbi.nlm.nih.gov/pubmed/28126413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.01.012
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