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Phagolysosome Acidification is Required for Silica and Engineered Nanoparticle-induced Lysosome Membrane Permeabilization and Resultant NLRP3 Inflammasome Activity
NLRP3 inflammasome activation occurs in response to hazardous particle exposures and is critical for the development of particle-induced lung disease. Mechanisms of Lysosome Membrane Permeabilization (LMP), a central pathway for activation of the NLRP3 inflammasome by inhaled particles, are not full...
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| Udgivet i: | Toxicol Appl Pharmacol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5326503/ https://ncbi.nlm.nih.gov/pubmed/28126413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.01.012 |
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